Multiple Sclerosis Severity Scale and whole-brain N-acetylaspartate concentration for patients’ assessment
نویسندگان
چکیده
منابع مشابه
Longitudinal whole-brain N-acetylaspartate concentration in healthy adults.
BACKGROUND AND PURPOSE Although NAA is often used as a marker of neural integrity and health in different neurologic disorders, the temporal behavior of WBNAA is not well characterized. Our goal therefore was to establish its normal variations in a cohort of healthy adults over typical clinical trial periods. MATERIALS AND METHODS Baseline amount of brain NAA, Q(NAA), was obtained with nonloc...
متن کاملSerial whole-brain N-acetylaspartate concentration in healthy young adults.
Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was ...
متن کاملReproducibility of three whole-brain N-acetylaspartate decline cohorts in relapsing-remitting multiple sclerosis.
BACKGROUND AND PURPOSE The cross-sectional rate of whole-brain N-acetylaspartate (NAA, a neuronal cell marker) loss in clinically similar relapsing-remitting multiple sclerosis (RRMS) patients has recently been shown to fall into 3 distinct decline rate strata. Our goal was to test the reproducibility of this observation in a new cohort of RRMS patients. MATERIALS AND METHODS Sixteen serial p...
متن کاملWhole-Brain N-Acetylaspartate Concentration Comparison of Young and Elderly Healthy: Evidence for Brain Durability
Introduction: An estimated 40 million Americans are currently 65 years of age or older, with that number expected to grow to 70 million by 2030 (1). Since several neurological conditions, especially Alzheimer’s Disease (AD) and the broad spectrum of ischemic disorders, afflict the elderly, the burden of these diseases to healthcare delivery will soon become staggering. Although it has been show...
متن کاملWhole-brain N-acetylaspartate concentration: correlation with T2-weighted lesion volume and expanded disability status scale score in cases of relapsing-remitting multiple sclerosis.
BACKGROUND AND PURPOSE The T2-weighted MR imaging total lesion volume and Expanded Disability Status Scale (EDSS) score are two common measures of relapsing-remitting multiple sclerosis disability and pathologic abnormality. Because the whole-brain N-acetylaspartate concentration is considered to be a new marker of the disease burden, the purpose of this study was to evaluate the relationship a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2011
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458511415142